NOTE:In dogs, the manufacturer recommends a starting dose of 0.5 U/kg q 24 hr. Because lauric acid can be a digestive irritant and not well tolerated when taken directly, monolaurin is the supplement form taken by most looking for the beneficial properties of lauric acid. The researchers concluded that monolaurin has great potential as a prophylactic. In this situation, the gut microbiome is compromised. It is recommended to start with low doses of monolaurin and slowly build up to a higher dose over time. Last medically reviewed on August 22, 2017. Monolaurin is made from extracting the lauric acid from coconut oil either by enzymatic hydrolysis, centrifugation, and distillation [Ref #7] or the combination of cold pressed coconut oil with purified glycerol via a shaking incubator [Ref #8]. ResearchGate. Additionally, over 60% of mice survived when receiving a daily combination of origanum oil and monolaurin [5]. Monolaurin may be taken at high levels for short periods of time. Monolaurin can be taken in a range of doses, which will depend on the end user. You can learn more about how we ensure our content is accurate and current by reading our. Research shows that monolaurin is an effective killer of bacteria, including antibiotic-resistant Staphylococcus aureus. economy size, which is 21 oz. Option for dogs; rarely recommended for cats due to short duration of effect. Annals of the New York Academy of Sciences. Learn what studies have to say about its ability to combat conditions from acne to. When researching and deciding to buy monolaurin, look for purity. WebIt is known as an alpha agonist.This drug is not recommended for use in children less than 2 years of age due to an increased risk of serious side effects such as very slowed breathing. Alternative & Complimentary Therapies, December 2006. There are about 80 pellets in a scoop (tsp.). A generally accepted dosage range is 1 -3 capsules 2 - 3 times daily (1800mg to 5400mg), but some customers prefer lower or Here are 9 teas that help treat stomach problems. Coconut oil consumption and cardiovascular risk factors in humans. 2016. Researchers are currently investigating its usefulness in clinical settings. This substance can then be capsulated and used as a dietary supplement or for other food / cosmetic purposes. It is also present in coconut milk, coconut water, and solid coconut. Monolaurin has been shown in research to treat infection with C. albicans, while also controlling the pro-inflammatory response of the body to the fungus. Monolaurin has been found in some studies to disrupt specific strains of salmonella with single lipopolysaccharide layers. At Inspired Nutrition, we have taken those results one step further by increasing the ratio that lauric acid is converted into monolaurin from 3% to 95%. Nonetheless, the results are promising, and research on humans and animals is ongoing. People with intestinal inflammation or risk of multiple sclerosis may need to limit their consumption of coconut and MCT oil, and, therefore monolaurin [57]. doi:10.1111/jam.12970, The results from this study showed that lauric acid has an anti-microbial effect. [Ref #36], Source: Goc A, Niedzwiecki A, Rath M. In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii. ProZinc (Boehringer Ingelheim Animal Health), CatsNadir 57 hr.Duration 824 hr.14DogsNadir 812 hr.23, Cats12 U per cat q 12 hr.Dogs0.250.5 U/kg q 12 hr.230.51 U/kg q 24 hr.15. Monolaurin has statistically significant in vitro broad-spectrum sensitivity against Gram-positive and Gram-negative bacterial isolates from superficial skin infections. The antimicrobial function of milk lipids. Journal of Bacteriology. Note:When selecting products, veterinarians have a choice among those formulated for humans and those developed and approved by veterinary use. Monolaurin - 500mg, Astragalus - 50mg, Beta Glucan - 50mg, Cat's Claw - 50mg, Olive Leaf - 50mg Directions As a dietary supplement, adults should take one (1) capsule daily or as recommended by a healthcare professional. Monolaurin research suggests it is able to inactivate lipid-coated viruses such as herpes, cytomegalovirus, influenza, and various pathogenic bacteria and protozoa in lab settings [Ref #1, 2, 3, 11, 12]. These products are specifically designed and formulated for dogs and cats and have benefits for their use; they are not human generic products. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. A study found that consumption of medium-chain fatty acids such as monolaurin from coconut oil helped in remodeling the gut microbiome by altering the distribution of good bacteria where they were needed the most [Ref #35]. WebStarting Dose. We avoid using tertiary references. Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from skin infections: An in vitro study [Abstract]. stuffy nose. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. / 85 pellets) a day for a 150 pound person . If one tablespoon of coconut oil were converted to 50% Monolaurin, you would need to take 6.5 teaspoons of coconut oil to achieve the amount of Monolaurin in one 600mg capsule (assuming one teaspoon of coconut oil is 0.924 g/cm3 [grams per cubic centimeter] is approximately 184.8 milligrams). These include several species of ringworm and the parasite, Giardia lamblia. Drug class: Ophthalmic glaucoma agents. Journal of Food Safety 4:1-12 (1982), Goc, A., Niedzwiecki, A. and Rath, M. (2015), In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii. "The most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. All quotes below are taken directly (verbatim) from published studies and are not the opinion of this site. These statements have not been evaluated by the Food and Drug Administration. Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals. Read more about Taking too much Monolaurin. But quantity limits in standardized foods with nutritional labeling, like granola bars, may exist. Here are 5 potential benefits of 5-HTP, Ritual is a subscription-based vitamin company that offers protein powders and multivitamins for people of all ages. Monolaurin (also known as glycerol monolaurate) is a medium chain fatty acid formed from lauric acid. Kabara JJ. Under 130 pounds: 1 scoop, 2 times daily. The majority of studies have looked at the effects of monolaurin on viruses, bacteria, and fungi in test tubes and petri dishes. Cianferoni A, et al. I keep monolaurin on hand for my cats, because it cures cytauxzoanosis (bobcat tick fever), which is often fatal. No clinical evidence supports the use of monolaurin for infections or any of the conditions listed in this section. Healthline only shows you brands and products that we stand behind. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 2015 Oct;16(5):538-42. doi: 10.1089/sur.2014.162. Information is shared for educational purposes only. Other benefits of lysine include: helping the body absorb calcium, iron, and zinc. It is not yet known if medicinal amounts of monolaurin are safe. EveryPlate's meal kits may cost less than those of other companies. We believe that the most accurate information is found directly in the scientific source. Last updated on Aug 22, 2022. doi:10.1111/jam.12970, FDA : 21CFR184.1505 ; https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1505, Sumit NANDI, Sarbani GANGOPADHYAY, Santinath GHOSH, Production of Medium Chain Glycerides and Monolaurin from Coconut Acid Oil by Lipase-Catalyzed Reactions, Journal of Oleo Science, 2004, Volume 53, Issue 10, Pages 497-501, Released September 10, 2004, Online ISSN 1347-3352, Print ISSN 1345-8957, Pinyaphong, P., Sriburi, P., & Phutrakul, S. Synthesis of Monoacylglycerol from Glycerolysis of Crude Glycerol with Coconut Oil Catalyzed by Carica papaya Lipase. World Academy of Science, Engineering and Technology International Journal of Chemical and Molecular Engineering. Best taken regularly over time for results. Cats0.5 U/kg q 12 hr if BG > 360 mg/dL.0.25 U/kg q 12 hr if BG < 360 mg/dL. 2010;5: 3. Monolaurin is a naturally-occurring fat present in both coconut oil and breast milk [1, 2]. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Monolaurin has not been evaluated by the FDA for any medical condition, while clinical studies are few. ALPHAGAN P ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. Monolaurin has been tested and researched for its potential effects on enveloped viruses including Herpes, Epstein-Barr, and Influenza, as well as bacterial and yeast infections in certain lab settings [Ref# 3, 4, 5]. Lauric acid converts to monolaurin in the body [4, 5]. Supporters are investigating whether monolaurin may assist in weight management by killing these stored viruses, though no valid evidence has yet been published [49]. While monolaurin has GRAS (Generally Recognized as Safe) status from the United States Food and Drug Administration (FDA), it has not been evaluated as a treatment for any condition. Dietary supplements are not regulated, so beware of unfamiliar additives. In addition, comparing per-U costs of insulin is more useful than comparing cost per vial. Monolaurin was researched against the parasite Giardia lamblia [38]. WebDosage must be individualized. Thormar, H; Isaacs, C E; Brown, H R; Barshatzky, M R; Pessolano, T (1 January 1987). All rights reserved. ALPHAGAN P ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. 10:271-85, 2001. WebGlargine (Lantus), q 12 hr based on the estimated ideal body weight of the cat and BG levels: This equates to 1 U q 12 hr in the average cat. It should be noted that product pharmacokinetics vary depending on insulin type, product formulation, and the individual patients response. Some people may find this unpleasant or inconvenient. 2023 American Animal Hospital Association. Taking it with a hot beverage can make the taste worse. Allergen Warning: Contains Tree Nuts (Coconut). Source: Hess DJ, Henry-Stanley MJ, Wells CL. WebMaximum Dosage - Monolaurin has no determined upper limit, but caution should be taken when dosages exceed 6 grams/ day Food - Monolaurin may be taken on an empty Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, Imperfect Foods review: What to know in 2023, Daniel Bubnis, M.S., NASM-CPT, NASE Level II-CSS, Caffeine withdrawal: Drinking good decaf coffee may reduce symptoms, preventing and treating bacterial, fungal, or viral infections, treating some antibiotic-resistant infections, such as. Surg Infect (Larchmt). I give one 300-milligram capsule once an hour for eight doses, emptied out and mixed with water and given with an eyedropper. The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates of Staphylococcus epidermidis 16 December 2019 | BMC Proceedings, Vol. Serving Size: 1 scoop(1 tsp., about 80 pellets) = 3,000 mg. Other Ingredients: Glycerol. Packaging Features (Safety and Quality Control Measures): An important but often overlooked component of supplements are the physical packaging and safety features put in place. The Herxheimer (Herx, sometimes Herxing) Reaction or "Die off" symptom is a side effect producing symptoms ironically similar to a cold or flu. Consider using the lower end of the starting dose for a large dog and higher end for a small dog. Seleem, D., Chen, E., Benso, B., Pardi, V., & Murata, R. M. (2016, June 22). Then their health would begin to suffer - while those on native diets stayed healthy! It is also used to treat chronic fatigue syndrome (CFS) and to boost the immune system. Imperfect Foods aims to reduce food waste by selling foods that grocery stores reject. MS: Can the Mediterranean diet help preserve cognitive health? Ezigbo, Veronica O., Mbaegbu Emmanuella A. ii) It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. Much later, Michigan State University researchersdiscovered what happened when we eat coconut. 1972; 2(1):23-28. doi:10.1128/aac.2.1.23, "Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction", Source: Ruzin A, Novick RP. Candida albicans is a common fungal pathogen that lives in the gut, mouth, genitals, urinary tract, and skin. If more than one topical ophthalmic product is to be used, the Monolaurin is a very hardy substance and tests indicate high heat nor humidity effect the efficacy or stability of the product. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. Antimicrob Agents Chemother. One teaspoon of our monolaurin has3,000 mg! Use Alphagan (Ophthalmic) exactly as directed on the label, or as prescribed by your doctor. A recent study found that monolaurin has potential as an antifungal treatment for candida albicans one that can also reduce a pro-inflammatory response. http://aocs.files.cms-plus.com/inform/2005/6/p386-387.pdf, https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1505, https://www.nhs.uk/conditions/leaky-gut-syndrome/. Disclaimer: The research below is offered for information and educational purposes only and is not intended to provide medical advice. Current scientific research into monolaurin is limited. P73. The general recommended dose of monolaurin is 1 to 3 grams for adults. Results may vary. Monolaurin specifically wasnt studied, though [49]. Acute effects of dietary fatty acids on the fatty acids of human milk. [Ref #37], Source: Horowitz, Richard. All rights reserved. This Drug Interactions and Toxicity: There is a collection of research which explores potential monolaurin benefits through in-vitro (outside a living organism) and in-vivo (inside a living organism) studies select excerpts can be found on the Monolaurin Research page. The richest food source of lauric acid is coconut oil, with certain coconut products consisting of nearly 50 percent lauric acid. If experiencing a due off or herx reaction you should consider reducing or limiting the supplement until your body is able to better cope with the die off and drink plenty of fluids to aid in the removal of cytokines and proteins in the system. Our body adds glycerol to the lauric acid in coconut and converts about 3% of it into a nutrient called. Page 4 of 26 Children (2-18 years of age): The use of ALPHAGAN P is currently not recommended in children, as several serious adverse reactions have been reported in association with the administration of brimonidine tartrate ophthalmic solution 0.2% in pediatric population. DOI: Elmore LK, et al. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Known as the woman's herb, red raspberry leaves have been used during pregnancy and to treat various ailments for centuries. Dr. Kabara discovered monolaurin and markets it under the brand name Lauricidin. In Vitro Effects of Monolaurin Compounds on Enveloped RNA and DNA Viruses. Carpo, B. G., Verallo-Rowell, V. M., & Kabara, J. One teaspoon of our monolaurin has3,000 mg! Since monolaurin is in its highest concentration in naturein mother's milk, they suspected monolaurin might be the magic bullet responsible. Learn about antifungal essential oils and their benefits for ringworm, athletes foot, and more. Enjoyonlinesavings! Dermatitis: November-December 2008 - Volume 19 - Issue 6 - p 308315 doi: 10.2310/6620.2008.08052. Monolaurin can be taken at modest levels (around 3 grams/ day) with little or no side effects, but caution should be exercised when doses exceed 6 grams / day. ALPHAGAN P (brimonidine tartrate) ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. Pellets Vs. This is your body's immune response to what it thinks is an infection. You should not take so much monolaurin that you feel unwell (upset stomach, diarrhea, headache, etc.). Consider some of the products located on this external site: Shop Monolaurin. Volume 20, Issue 4, October 2002, Pages 258262. Nutrients. The opinions expressed in this section are solely those of the users who may or may not have medical or scientific training. Existing research explores monolaurins potential to exhibit antiviral, antibacterial, and antifungal properties in controlled laboratory studies.